5/30/2023 0 Comments The wealth of networks![]() ![]() Overall, we show that the network topology is vital in phenotype diversity in regulatory circuits. We validate our findings against the Gal promoter system in the yeast cell. ![]() ![]() We capture this signature by calculating stochastic potentials and at- tributing their multi-stability features. The Wealth of Networks is an indispensable guide to the political economy of our digitally networked world.'Jack M. We also find that the higher-order networks exhibit alternative steady states from the stochastic dynamics of each network. We characterize each possible network of interactions by systematic variations of free energy parameters associated with the binding among biomolecules and DNA loop- ing. Our theoretical and Monte Carlo simulations show that a complex network of interactions can form a decision-making loop, such as feedback and feed-forward circuits, only by a few molecular mechanisms. ![]() Here, we demonstrate how the coordinated self-assembly creates gene regulatory network motifs that cor- roborate the existence of a precise functional response at the molecular level using thermodynamic and dynamic analyses. The apparent structure of those complex assemblies is very similar, but their func- tional response strongly depends on the topology of the protein-DNA interaction networks. Cooperative protein-protein and protein-DNA interactions form programmable complex assemblies, often performing non-linear gene regulatory operations involved in signal transductions and cell fate determination. ![]()
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